AKT1 and cancer: The mTOR signaling plays a central role in cancer progression [29], and its activation has been observed in cervical cancer by immunocytochemical staining of certain components of mTOR signaling, such as upregulated expression of mTOR and p70S6K and elevated phosphorylation of mTOR, S6 and Akt-Ser473 in cervical cancer tissues [25, 26, 30, 31].