Referred to the uptake assay results of DF-HSA in pancreatic cancer cells, there existed an intensive macropinocytosis-mediated intracellular entry of DF-HSA in MIA PaCa-2 cells, which was much higher than that in BxPC-3 cells, these indicate that the inhibitory effect of DF-HSA is a macropinocytosis-mediated action of the albumin-integrated β-defensin remained active while being brought into the cell. Here, ALB is linked to pancreatic neoplasm.