Recently, carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), another well‐known molecule expressed on activated T cells and involved in T‐cell inhibition, was identified as a heterophilic ligand for Tim‐3 that is required for its ability to mediate T‐cell inhibition, and this interaction has a crucial role in regulating autoimmunity and anti‐tumor immunity 4. This evidence concerns the gene HAVCR2 and neoplasm.