A different small molecule, WP1130 and its improved derivative EOAI3402143 based on second-generation tyrphostin derivatives [initially identified as Janus-activated kinase (JAK)-signal transducer], appear to inhibit USP9X and USP24 and consequently increased Myeloma tumor cell apoptosis in vitro and in vivo (Peterson et al., 2015). This evidence concerns the gene USP24 and neoplasm.