BAP1 and cancer: Although the majority of the published studies suggest that the effects of BAP1 in cancer involve a disruption of the epigenetic homeostasis in these tumors (Wang Y. et al., 2014), for some researchers, it is not so clear that the antitumor effect of BAP1 is only dependent on H2A deubiquitylation (Pena-Llopis et al., 2012).