Overexpression of this DUB has been found in colorectal cancer (Liu Y.L. et al., 2011), gastric cancer (Yang et al., 2011; He et al., 2015), liver cancer (Tang et al., 2015a,b), breast cancer (Zhang Y. et al., 2011), glioma (Liang J. et al., 2014), pancreatic cancer (He et al., 2015), non-small-cell lung cancer (Hu et al., 2012), salivary adenoid cystic carcinoma (Dai et al., 2014), human pharyngeal squamous cell carcinoma (Dou et al., 2014), and oral squamous cell carcinoma (Piao et al., 2012). This evidence concerns the gene ZUP1 and central nervous system cancer.