The independent variables used in the simple logistic regression model include age, gender, educational attainment, history of smoking and drinking, duration of diabetes, FBG, HbA1c, fasting C peptide, C peptide (120 min), TG, TC, LDL-c, HDL-c, serum creatinine, eGFR, blood uric acid, TSH, SBP, DBP, prevalence of hypertension, CVD, diabetic nephropathy, neuropathy, plasma clusterin level and CLU genotype. The gene discussed is CLU; the disease is neuropathy.