Compared with the studies indicating that the rs1113600 minor T allele occurs less frequently in AD patients than in cognitively healthy control patients and that CLU rs11136000 CC genotype is a the risk factor for AD (Bertram et al., 2007; Carrasquillo et al., 2015), our study found no difference in the distribution of genotype and allele frequencies of CLU rs11136000 in T2DM patients with MCI and controls, possibly because of the low minor allele frequency in Chinese and the small sample size. The gene discussed is CLU; the disease is Alzheimer disease.