The independent variables used in the simple logistic regression model include age, gender, educational attainment, history of smoking and drinking, duration of diabetes, FBG, HbA1c, fasting C peptide, C peptide (120 min), TG, TC, LDL-c, HDL-c, serum creatinine, eGFR, blood uric acid, TSH, SBP, DBP, prevalence of hypertension, CVD, diabetic nephropathy, neuropathy, plasma clusterin level and CLU genotype. This evidence concerns the gene CLU and diabetes mellitus.