CCN2 and familial dilated cardiomyopathy: We studied serum markers of fibrosis from various groups and points of action, including markers of collagen synthesis (PICP, PINP, PIIICP, PIIINP, collagen-1), fibrosis controlling factors (TGFβ and CTGF), and enzymes degrading collagen fibers (MMP-2, MMP-9, and TIMP-1) in homogenous DCM cohort with significant LV remodeling and LV systolic dysfunction.