To investigate the impact of B4GALT1 on SOCS3-induced chemo-sensitivity promotion in leukemia cells, K562 cells which stably over-expressed SOCS3 were transduced with the B4GALT1 expression vector or its negative control and then we examined apoptosis ratios of K562 cells in different groups after imatinib treatment. This evidence concerns the gene B4GALT1 and leukemia.