The pathways and genes that significantly changed were classified as follows: cancer pathways (EPAS1, CCND1, FGF13), myeloid leukemia pathways (ZBTB16, KIT, IL13), hematopoietic cell lineage pathways (EPOR, GYPA, CD36) and so on (Fig. 4). The gene discussed is ZBTB16; the disease is cancer.