The opposite prognostic effect of NDUFS1 of NADH dehydrogenase module and NDUFS8 of hydrogenase module revealed in our survival analysis is the clinical evidence of the oncojanus role of complex I. Figure 3C showed representative NDUFS1 and NDUFS8 IHC staining images of two NSCLC cases. This evidence concerns the gene NDUFS1 and non-small cell lung carcinoma.