Infusion of FdCyd in R6/2 brains significantly upregulated the expression of striatal Drd2, Ppp1r1b, Rasd2, and Adora2a mRNAs and also showed a trend towards increasing Penk mRNA (Fig. 5B), indicating that pharmacological inhibition of DNMTs can correct transcriptional deficiencies in HD mouse brain. This evidence concerns the gene PENK and Huntington disease.