In support of the present results, Hatano et al. showed that TRPA1 gene expression was enhanced in synoviocytes by inflammatory factors TNF-α and IL-1 [12], and the present study together with that of Hatano et al. [12] suggests a previously unrecognized mechanism that links TRPA1 as an inducible factor to joint inflammation. This evidence concerns the gene IL1B and inflammatory response.