Treatment of Detroit-562 xenografts by systemic αvβ6-blocking antibody 6.3G9 or soluble recombinant TGFBRII-Fc protein suppressed tumour growth but did not significantly change the expression of αSMA, CD31-positive blood vessels or collagen deposition detected by Sirius red staining (Van Aarsen et al. 2008). This evidence concerns the gene ACTA1 and neoplasm.