A key mediator between intracellular TGFβ signalling and transmembrane integrins in endothelial cells is endoglin, a TGFβ superfamily accessory receptor that is expressed in the angiogenic vessels of brain, lung, breast, stomach and colon cancers (Minhajat et al. 2006). Here, TGFB1 is linked to malignant colon neoplasm.