TGFB1 and neoplasm: CYR61 appears to function as a tumour suppressor or promoter depending on which integrin is engaged.The binding of CYR61 to α6β1 generates senescence-inducing reactive oxygen species in fibroblasts, associated with reduced TGFβ1 expression, or induces p53-dependent apoptosis, therefore protecting against aberrant cell proliferation and fibrosis (Jun and Lau 2010; Lau 2011).