TGFB1 and neoplasm: In contrast, Eberlein and colleagues (2013) reported that the treatment of mice bearing Detroit-562 xenografts with 264RAD, a human antibody that inhibits αvβ6, resulted in a dose-dependent reduction in tumour growth that was mirrored by a dose-dependent reduction in fibronectin and SMA, two products of TGFβ-activated fibroblasts, suggesting strongly that αvβ6 was promoting a myofibroblast-rich microenvironment.