PTEN and breast cancer: To assess 18F-FDG PET as a biomarker for AZD8186 in population enriched for PTEN deficiency, we measured 18F-FDG uptake and AKT pathway activity biomarkers in PTEN null (786-0 renal and U87-MG glioma in vivo models) and compared it to the results acquired in a PTEN-proficient BT474C breast cancer xenografts.