Simultaneous treatment with 10 μM rucaparib or olaparib effectively halved the external beam X-radiation dose or the 131I-MIBG activity concentration required to kill 50 % of clonogens (IC50) derived from human neuroblastoma SK-N-BE(2c) cells, and human glioma UVW cells genetically engineered to express the noradrenaline transporter (NAT). Here, BRD2 is linked to glioma.