In the next few paragraphs, we focus on a small sampling of these TASC-derived factors as examples (the pro-inflammatory cytokines and chemokines IL-6, CXCL1, IL-1β, and TNF-alpha) and discuss their contribution towards signaling in the tumor microenvironment and stimulation of additional TASC-derived factors in detail. This evidence concerns the gene CXCL1 and neoplasm.