In the majority of sub-Saharan Africa, without a diagnosis of tuberculosis (TB) or World Health Organization (WHO) stage IV opportunistic infection, only HIV-positive individuals with a CD4+ T cell lymphocyte count below a certain threshold are eligible to initiate ART, [5] therefore CD4 cell count determination is a required step towards treatment initiation and therapeutic success [6]. This evidence concerns the gene CD4 and Opportunistic infection.