The activation of three stringent UPRs related to DNA damage pathways [43–45] in both GL261 and LLC tumors (CHUK/IKBKA, IKBKB and JUN) or in all three tumor models (CHUK, IKBKB) (Additional file 4: Table S3A-C) may reflect the cytotoxic responses common to CPA treatment in all three tumor models. This evidence concerns the gene CHUK and neoplasm.