EIF2AK2 and viral infectious disease: Further, three activated UPRs associated with immune activation were unique to CPA/6d-treated GL261(B6) tumors: EIF2AK2 is an intracellular danger-sensing molecule important for inflammasome activation and HMGB1 release [26]; IFNL1 can mediate inflammatory responses in epithelial cells [60, 85]; and MAVS is required for activation of NFkB and interferon induction in response to viral infection [61].