CSF2, which stimulates intra-tumoral dendritic cell expansion and induces significant CD4+ and CD8+ T cell anti-tumor immune responses [41, 42] was the top uniquely activated UPR (most significant UPR, based on p-value of overlap) in CPA-treated GL261 tumors (Table 2, Additional file 4: Table S3G). This evidence concerns the gene CD4 and neoplasm.