SPARC and neoplasm: Three activated UPRs associated with immune activation were unique to CPA/6d-treated GL261(B6) tumors: EIF2AK2 [26], IFNL1 [60] and MAVS [61], while the two activated UPRs specific to GL261(scid) tumor responses, DMD [62] and SPARC [34–36], have glial cell-related functions:.