IRS2 and coronary artery disorder: Data from Vats et al have shown that a single-nucleotide polymorphism (SNP) in IRS2—Gly(1057)Asp—is also associated with CAD, where Gly(1057)Asp carriers or Asp1057 homozygous individuals have an increased risk of developing CAD in the overall population of Punjabi origin, and in obese individuals [22].