We analyzed the effect of oligomeric Aβ1-42, a toxic peptide abundantly present in AD brains, on cdh1 in vitro and in vivo. Furthermore, we tested the role of glutamate on APC/C-Cdh1 activity in neuron culture, since it has been reported that glutamate excitotoxicity dysregulates cdh110. Here, APC is linked to Alzheimer disease.