Using a mouse model of tissue specific mutation of the Foxl2 gene which recapitulated the phenotypes of the human blepharophimosis, ptosis and epicanthus inversus syndrome (BPES), it has been shown that defective development of cranial neural crest and mesodermal cell derived muscles and skeletal components would prevent eyelid closure [33]. The gene discussed is FOXL2; the disease is Blepharophimosis.