UBE2I and acute myeloid leukemia: Relevantly, it has been shown in acute myeloid leukemia cells that chemotherapeutic drugs ROS-dependently inhibit the SUMO-conjugating enzyme UBC9, and that pro-oxidants or inhibition of the SUMO pathway by anacardic acid are able to initiate apoptosis in chemoresistant patient samples and leukemic stem cells [75].