In support of this notion, inhibiting constitutively activated STAT3 resensitizes drug-resistant lymphomas and myelomas to cisplatin, fludarabine, adriamycin, and vinblastine-induced apoptosis [51], and pairing the cyclooxygenase inhibitor ibuprofen with pharmacological system xc- inhibition using sulfasalazine synergistically improves its antitumor efficacy in a murine sarcoma model [76]. This evidence concerns the gene STAT3 and sarcoma.