These genes include PRF1 (related with FHL type 2), UNC13D (related with FHL type 3), STXBP2 (related with FHL type 5), STX11 (related with FHL type 4), SH2D1A (related with X-linked proliferative syndrome type 1, XLP), XIAP (related with X-linked proliferative syndrome type 2, XLP2), RAB27A(related with Griscelli Syndrome 2), LYST(related with Chediak–Higashi Syndrom), AP3B1(related with Hermansky–Pudlak. This evidence concerns the gene AP3B1 and X-linked lymphoproliferative disease.