Additionally,by dividing HLH patients into 2 groups according to the average expression value of SRSF1, we surprisingly found the HLH patients group with low SRSF1 expression level had significantly elevated STXBP2 expression level (unpaired t test, p = 0.048)(S1 Fig), such connections could be a factor that, when combined with gene polymorphisms, would modulate STXBP2 gene function and further influence the pathological process in HLH patients. This evidence concerns the gene STXBP2 and hemophagocytic syndrome.