LGALS3 and neoplasm: Drug resistance is considered a characteristic of tumor-initiating stem cells.20 Gal3 has been associated with drug-resistance.21, 22 We therefore subjected Gal3-depleted colon cancer CSC and pancreatic cancer CSC to clinically relevant chemotherapeutic regimens, FOLFOX (5-fluorouracil, oxaliplatin, leucovorin) and FOLFIRI (5-fluorouracil, irinotecan.