LGALS3 and neoplasm: This is in keeping with the many biological functions previously reported for extracellular and intracellular Gal3.28 Substantial evidence indicates that Gal3 contributes to neoplastic transformation and tumor survival (including resistance to apoptosis), and other events associated with metastasis28 It is not known whether Gal3 expression is associated with all of the same functions in CSC as in non-stem cells, but several of the functions previously reported to be associated with Gal3 were enhanced in Gal3-positive CSCs.