The human colorectal cancer cell line LS-LiM6 (LiM6) was originally established by serial in vivo passaging of LS-174T cells that were implanted into the cecum of athymic mice and re-isolated from their liver lesions.11 As another representative colorectal cancer cell line, we used the well-described cell line DLD1.12 We recently described derivatives of LiM6 and DLD1 that were highly resistant to TRAIL treatments; these sub clones were utilized due to their heightened surface Gal3 expression and named LiM6-TR and DLD1-TR, respectively.10 The gene discussed is LGALS3; the disease is colorectal cancer.