TNFRSF10B and cancer: As a response to anticancer treatments, whether autophagy activation leads to cell survival or cell death remains unclear.34 Previous studies have suggested that the induction of autophagy could be a useful therapeutic approach by which to overcome drug resistance of cancers to some therapeutic agents, particularly those that typically induce an apoptotic response.35, 36 Here, we found that CK increases LC3-II and Atg7 expression, indicating the onset of autophagy, and pretreatment with 3-MA, LY294002 or Atg7 siRNAs, which inhibits autophagy, reduces DR5 expression.