To investigate whether CK could synergize with TRAIL to inhibit the colon cancer cell viability, a panel of TRAIL-sensitive colon cancer cell lines including HCT116 (Figure 1a), colo205, DLD-1, SW480 (Supplementary Figure 1a) cells and TRAIL-resistant HT-29 (Figure 2a) cells were tested. The gene discussed is TNFSF10; the disease is malignant colon neoplasm.