Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF cytokine family, is a potent cancer cell-specific apoptosis-inducing agent that exhibits little or no effect on normal tissues.1, 2, 3 TRAIL can bind to five distinct type I transmembrane receptors, two of which are death receptors, DR4 (TRAIL-R1) and DR5 (TRAIL-R2), and three of which are decoy receptors, DcR1 (TRAIL-R3), DcR2 (TRAIL-R4) and osteoprotegerin. The gene discussed is TNFRSF10D; the disease is cancer.