It has been reported that CK could induce autophagy in human colon cancer cells.25 The accumulation of autophagosomes in TRAIL-resistant breast cancer cells induces TRAIL resistance through downregulation of surface expression of DR4 and DR5.26 Here we investigated whether autophagy was related with the DR5 induction by CK and potentiation of CK on TRAIL-induced apoptosis. Here, TNFRSF10B is linked to colonic neoplasm.