BCL2 and cancer: lncRNA-LET, for example, is downregulated by hypoxia in gallbladder cancer cells conferring apoptotic resistance, whereas ectopic expression of lncRNA-LET leads to an increased BAX/BCL-2 ratio, caspase-3 activation, and apoptosis.171 The crucial role of lncRNA in cancer is also highlighted by their relationships to some key oncogenes.