PDCD4 and injury: For instance, in heart ischemia–reperfusion injury (IRI), fluctuations of miR-1, miR-21, miR-29, miR-92a, miR-133, miR-199a and miR-320 levels change the expression of many miRNA-regulated genes, including phosphoinositide 3-kinase, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), Bcl-2, Mcl-1, HSP60, HSP70, HSP20, programmed cell death 4 (Pdcd4), LRRFIP1, Sirt-1, etc., which can individually or collectively trigger intrinsic apoptosis and thus affect the severity and manifest of injury.57