Second, lncRNAs may suppress miRNA expression, as can be demonstrated by the example of lnc HULC, which suppresses the expression of the CREB-targeting miR-372 in HCC, and therefore affects CREB-mediated epigenetic modifications that govern the expression of a series of cell death/survival related genes.183 The regulatory relationship between a given pair of lncRNA–miRNA may be not only unidirectional but also bidirectional, which further interweaves the regulatory network among lncRNA, miRNA and cell death. This evidence concerns the gene CREB1 and hepatocellular carcinoma.