In B-cell malignancies such as chronic lymphocytic leukemia (CLL), the overexpression of BCL2 is concomitant with the marked downregulation of two miRNAs: miR-15 and miR-16, both induce apoptosis by suppressing BCL2 when ectopically expressed.48 The typical binding sites of numerous BCL2-inhbiting mRNAs, such as miR-195 miR-24 and miR-365-2, are within the 3'-UTR. The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.