The model has also proven useful in dissecting the role of poor prognostic biomarkers, such as BRMS1 and FSP1, in vitro22, 28, and for the identification and functional assessment of novel biomarkers of progression from ductal carcinoma in situ (DCIS) to invasive disease with both three‐dimensional (3D) culture and in vivo models 21, 23, 29. Here, BRMS1 is linked to ductal breast carcinoma in situ.