All histologic types of NSCLC have higher plasma Ang2 than control, with 2596 ± 1353 in adenocarcinoma (n = 122, P < 0.001), 2831 ± 1426 in squamous cell carcinoma (n = 86, P < 0.001), and 2739 ± 977.8 pg/mL in other types (n = 19, adenosquamous 8, large cell 6, carcinoid tumor 2, unclassified 3, P < 0.001) (Fig. 1C). This evidence concerns the gene ANGPT2 and adenocarcinoma.