The incidence of KRAS and GNAS mutations in patients with IPMN according to the patient’s sex was compared in eleven (Fritz et al. 2009; Hosoda et al. 2015; Kobayashi et al. 2008; Kondo et al. 1997; Mulligan et al. 1999; Schönleben et al. 2008; Singhi et al. 2014; Tada et al. 1991; Uemura et al. 2003; Wada et al. 2004; Wu et al. 2011b) and six (Hosoda et al. 2015; Ideno et al. 2015; Kanda et al. 2013; Singhi et al. 2014; Takano et al. 2014; Wu et al. 2011b) studies, respectively. Here, GNAS is linked to pancreatic intraductal papillary-mucinous neoplasm.