The frequency of GNAS mutation did not differ among high, intermediate, and low grades of IPMN patients (OR 0.769, 95 % CI 0.382–1.547, P = 0.461, Q = 15.126, I2 = 60.334; OR 1.273, 95 % CI 0.786–2.060, P = 0.326, Q = 2.789, I2 = 0.000, and OR 0.938, 95 % CI 0.500–1.761, P = 0.843, Q = 12.357, I2 = 51.445, respectively). Here, GNAS is linked to pancreatic intraductal papillary-mucinous neoplasm.