On the other hand, four studies (Amato et al. 2014; Sakamoto et al. 2015; Tan et al. 2015; Wu et al. 2011a) described the prevalence of RNF43 mutation among 143 IPMN patients (Additional file 1: Table S1). This evidence concerns the gene RNF43 and pancreatic intraductal papillary-mucinous neoplasm.