Synovial fluid, synovial fibroblasts, and macrophages from RA patients express high levels of anti-apoptotic Bcl-2 family proteins4, 5, and synovial fluid from RA patients protects neutrophils from apoptosis in vitro due (at least in part) to the presence of accumulated pro-inflammatory mediators and anti-apoptotic stimuli within the fluid1. The gene discussed is BCL2; the disease is rheumatoid arthritis.