There were several downregulated miRNAs from our dataset that were predicted to target TBX-21 and STAT4. These observations suggested that several of the up-regulated genes in the PBMCs of PTSD patients could be resulting from the decreased presence of miRNAs, as a result of their downregulation, that target the genes post transcription. The gene discussed is TBX21; the disease is post-traumatic stress disorder.