The value of monitoring mutant GATA1 clones after diagnosis is currently not clear; this would require an extremely sensitive method and an important limitation is that neonates with TAM may have more than one GATA1 mutant clone and that ML-DS may develop from either or both major and minor GATA1 clones present at birth [11••, 12••]. This evidence concerns the gene GATA1 and Dravet syndrome.