This is re-enforced by the following observations: 1) administration of the GR antagonist, RU486, reverts multiple features of AD pathology15, 16; 2) repeated stress worsens AD-induced deficits43; 3) elevated cortisol levels are associated with a faster disease progression in AD5; 4) systemic administration of glucocorticoids or stress potentiate memory impairments, hippocampal damage, β-amyloid formation and Tau pathology in transgenic AD mice6, 8, 44. Here, MAPT is linked to Alzheimer disease.