CTLA4 and colorectal carcinoma: Highly suppressive LAP+ and GARP/LAP co-expressing Tregs have been identified in TILs of CRC patients and the peripheral blood of pancreatic, CRC and anti-CTLA-4-treated bladder cancer patients, where their suppressive activity was mediated by TGF-β and IL-10 [44,55,56,57].