SPP1 and neoplasm: Interestingly, progressive tumors re-expressed genes involved in translation and cell growth (TGF-α, CKS1B, CKS2, RAN), and while continuing expressing pro-angiogenic (PDGF-β, VEGFA) and pro-invasive factors (SERPINE1, SERPINE2, SPP1), increased expression of genes involved in cytoskeleton remodeling (PLAU, PLAUR, ACTG1) and inflammation (IL6, IL8) and decreased expression of genes involved in cell adhesion (CDH1); several of these genes having pleiotropic functions that may be involved in tumor progression.