A good example is the identification of EWS gene rearrangements in Ewing's sarcoma, desmoplastic round cell sarcoma, extraskeletal myxoid chrondrosarcoma, myxoid liposarcoma, clear cell sarcoma and several other cancers [21]Similarly, KIT mutations and KIT protein expression has been identified in numerous tumors including GIST and other tumors unrelated to GIST [22]. The gene discussed is EWSR1; the disease is gastrointestinal stromal tumor.