This approach can also help in further classification of certain malignancies as recently highlighted in the new World Health Organization classification of hematopoietic malignancies which has categorized new entities with integrated nomenclature such as “myeloid neoplasm with PDGFRB rearrangement”, B-cell lymphoma with IRF4 rearrangement and high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangement [77]. This evidence concerns the gene IRF4 and B-cell non-Hodgkin lymphoma.