Receptor tyrosine kinase inhibitors, such as imatinib, sunitinib, and dasatinib, are used to treat GIST, acute myeloid leukaemia (AML), systemic mastocytosis, meningioma, dermatofibrosarcoma protuberans, and melanoma [29]. The gene discussed is NTRK1; the disease is acute myeloid leukemia.