TNF and hyperlipidemia: In line with this, we previously showed that systemic delivery of non-targeted full length IFNγ in mice results in leukocyte and endothelial cell activation, flu-like symptoms, neurotropic effects, hyperlipidemia, elevated TNF-α and IL-6, inflammation of the central nervous system, and elevated triglyceride levels [19], effects most likely mediated through binding to the widely expressed IFNγR.