Drp1 has already been implicated in the development of cancer of the breast, lung, skin and brain, but no common underlying mechanism has been reported in these findings: Drp1 has been proposed to alter mitochondrial energetics and cellular metabolism to sustain tumor development in melanoma [25], regulate stem cell maintenance in glioblastoma [30], promote metastasis in breast cancer [31] while maintain cell proliferation in lung cancer cells [32]. The gene discussed is DNM1L; the disease is breast cancer.