Moreover, the significant genes playing a role in synaptic vesicle membrane structure, including synaptotagmins I and XII (SYT1 and SYT12), vesicular glutamate transporter (SLC17A8), and GABA vesicular transporter (SLC32A1), were all inversely associated with GAK25; this association suggests GAK’s up-regulation in PD may be functionally related to these genes’ down-regulation and synaptic dysfunction. The gene discussed is GAK; the disease is Parkinson disease.