BRAF and melanoma: In the subsequent phase III coBRIM trial, 495 patients with treatment-naïve BRAF V600 mutation–positive melanoma were randomized to receive vemurafenib (960 mg BID) and cobimetinib (60 mg QD 21 days on and 7 days off) (combination group) or vemurafenib and placebo (control group) [21].