In the phase II expansion study, 162 advanced melanoma patients with BRAFV600 mutation and no prior BRAF targeted therapy were assigned 1:1:1 to receive dabrafenib (150 mg QD) and trametinib (either 1 or 2 mg QD) or dabrafenib (150 mg QD) monotherapy. The gene discussed is BRAF; the disease is melanoma.