Recently, encouraging results were also reported with agent that targets NRAS mutant melanomas in an open label phase III trial randomizing NRAS-mutant melanoma patients with or without prior immunotherapy 2:1 to binimetinib 45 mg BID (n = 269) or DTIC 1000 mg/m2 every 3 weeks (n = 133) [24]. Here, NRAS is linked to melanoma.