Collectively, these observations suggest that some of the CAPS-causativemutations in NLRP3 could promote inflammasome activation by facilitating theinteraction between NLRP3 and NEK7, but such a conclusion requires furtherelucidation of the mechanism by which NEK7 is involved in the activation ofdifferent NLRP3 variants. Here, NEK7 is linked to cryopyrin-associated periodic syndrome.