POU5F1 and type 2 diabetes mellitus: One of the first proof-of-principle studies64 generated iPSC lines from individuals with maturity-onset diabetes of the young (MODY) by using a polycistronic lentiviral vector overexpressing the so-called ‘Yamanaka factors’ (POU5F1 [OCT4],KLF4,SOX2, andMYC), these needed for somatic cell reprogramming to pluripotency42.