SOAT1 and inflammatory bowel disease: Knightset al., in a systematic analysis of the effect of 154 IBD-associated polymorphisms on microbial composition in three cohorts of patients with IBD (152 to 162 patients in each cohort) using multivariate linear models, reported that 49/154 IBD-associated genes significantly and concordantly affected microbial taxa in at least two of the cohorts, implicating the innate immune response, the inflammatory response, and the JAK-STAT cascade64.