In addition, omega-3 fatty acids diminish the expression of intercellular adhesion molecule-1, leukocyte adhesion to vascular endothelium, and the production of four biologically active molecules involved in the pathophysiology of tissue damage in SCD,namely the interleukins (IL)-1β, IL-6, and IL- 8 and tumor necrosis factor-alpha [85]. The gene discussed is IL1B; the disease is Schnyder corneal dystrophy.