In keeping with this, of the genes that occupy distinct radial positions in breast and/or prostate cancer, only MMP2 and ERBB2 are also commonly repositioned in non-malignant breast or prostate disease; but even for these gene it cannot be a general disease response as MMP2 repositions in prostate but not breast cancer and visa versa ERBB2 does not reposition in prostate cancer (Figure 2) (Meaburn et al., 2009; Leshner et al., 2016; Meaburn K. J. et al., 2016). Here, MMP2 is linked to prostate cancer.