Moreover, ten genes (FLI1, HES5, MMP9, HSP90AA1, TGFB3, MYC, ERBB2, FOSL2, CSF1R and AKT1) have been identified to reproducibly radially reposition in epithelial cells of breast cancer tissues (Meaburn et al., 2009, Meaburn K. J. et al., 2016) and FLI1, MMP9 and MMP2 occupy alternative radial locations in prostate cancer (Leshner et al., 2016). This evidence concerns the gene MMP2 and Familial prostate cancer.