Higher antibody titers are associated with improved survival of breast cancer patients, but elevations also correlate with adverse conditions, such as metabolic syndrome (177) and the early phase of acute coronary syndromes (e.g., myocardial infarction and unstable angina) – although in acute coronary syndromes, HSP27 antibody levels rapidly fall after a brief spike (175). This evidence concerns the gene HSPB1 and metabolic syndrome.