These researchers concluded that exercise “may thus interact with diet to alter pathological processes that ultimately modify AD risk.” That is particularly empowering in light of the later study (Baker, 2015) in which individuals aged 70 or older who maintained 70–80% of their maximum heart range for 45 min a day, 4 days a week for 6 months appreciated reduced phosphorylated tau levels in their cerebrospinal fluid with associated cognitive skill gains compared to a group whose exercise protocol was to stretch. This evidence concerns the gene MAPT and Alzheimer disease.