Longitudinal monitoring of CSF markers for autophagy might be worthwhile for individuals with known genetic risk factors for neurodegenerative disorders, such as homozygosity for the gene encoding for Apolipoprotein E4, which increases the risk of developing Alzheimer’s disease by 10-fold (Eisenstein, 2011; Rohn et al., 2014) and PD-associated mutations in the LRRK2 gene. Here, LRRK2 is linked to early-onset autosomal dominant Alzheimer disease.