Intriguingly, in contrast to previous molecular epidemiological findings [4, 7, 26], describing an association of the CASP8 -652 6N deletion variant or the CASP8 Asp302His variant with decreased breast cancer susceptibility, we showed that these caspase 8 variants have a negative and allele-dose dependent prognostic impact on breast cancer overall survival. The gene discussed is CASP8; the disease is breast cancer.