Interestingly the disease associations with specific SNPs in the TNFSF15 locus show opposite effects in leprosy and CD/PBC: the T allele at rs4979462 significantly increases risk of CD and PBC, but significantly decreases risk of leprosy; while at rs6478108, which only showed independent associations with CD and leprosy, the T allele significantly increases risk of CD, but significantly decreases risk of leprosy. Here, TNFSF15 is linked to leprosy.