BIRC5 and melanoma: Moreover, a luciferase reporter assay provides arguments to suggest that downregulation of survivin protein in SK-MEL-2 melanoma cells could be mediated by microRNAs (miRs), which have become increasingly important amongst epigenetic factors controlling tumorogenesis [47–49], probably generated by processing of the stem of the ASncmtRNAs by Dicer as a consequence of ASK [6].