MTOR and cancer: The dysfunction of the p38 MAPK and Akt/mTOR signaling pathways might be the principal mechanism for controlling the status of cancer survival, apoptosis, proliferation, and differentiation in response to intracellular signals like deregulation of the Wnt/β-catenin pathway, and extracellular signals from the inflammatory or tumorigenic microenvironment [30, 34].